DBU and copper(I) mediated carboxylation of terminal alkynes using supercritical CO2 as a reactant and solvent

Autor:	Fa-Wang Li, Quanling Suo, Ning Zhu, Hailong Hong, Limin Han, Ya-Qi Wang
Rok vydání:	2014
Předmět:	Propiolic acid Chemistry Ligand Organic Chemistry chemistry.chemical_element Biochemistry Copper Supercritical fluid Catalysis Solvent chemistry.chemical_compound Nucleophile Carboxylation Drug Discovery Polymer chemistry
Zdroj:	Tetrahedron Letters. 55:3878-3880
ISSN:	0040-4039
DOI:	10.1016/j.tetlet.2014.05.024
Popis:	An organic solvent free, DBU (1,8-Diazabicyclo[5.4.0]undec-7-ene)-mediated and copper(I)-catalyzed C H activating carboxylation of terminal alkynes in supercritical CO2 (ScCO2) was developed in this work. Terminal alkynes react with ScCO2 in the presence of CuI/DBU and produce the corresponding functionalized propiolic acids in excellent yields. Under the optimized conditions, carbon dioxide can act as both reactant and solvent for the reaction. DBU serves as a ligand of copper catalyst, nucleophile, and base during the reaction. DBU alone can also mediate the direct C H carboxylation in the absence of transit metal catalyst. But the reaction requires a higher reaction temperature and pressure to obtain desired yields.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::41f9f1b32538d593b7b8014bd414c10d https://doi.org/10.1016/j.tetlet.2014.05.024 Zobrazit plný text záznamu Full Text from ScienceDirect