Anticarcinogenic activity of methanol extract of Melastoma malabathricum leaves is attributed to the presence of phenolics compounds and the activation of endogenous antioxidant system
| Autor: | Noorsyaza Eddrina Kamsani, Roro Azizah, Lilis Sulistyorini, Zainul Amiruddin Zakaria |
|---|---|
| Rok vydání: | 2022 |
| Předmět: |
Pharmacology
chemistry.chemical_classification Melastoma malabathricum Antioxidant biology Traditional medicine Azoxymethane Glutathione peroxidase medicine.medical_treatment Endogeny Plant Science biology.organism_classification Superoxide dismutase chemistry.chemical_compound Complementary and alternative medicine chemistry Catalase Drug Discovery biology.protein medicine Aberrant crypt foci |
| Zdroj: | Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas. 21:66-80 |
| ISSN: | 0717-7917 |
| DOI: | 10.37360/blacpma.22.21.1.04 |
| Popis: | Melastoma malabathricum (M. malabathricum) extracts have been reported to exert various pharmacological activities including antioxidants, anti-inflammatory and antiproliferative activities. The objective of the present study was to determine the anticarcinogenic activity of its methanol extract (MEMM) against the azoxymethane (AOM)-induced early colon carcinogenesis in rats. Rats were randomly assigned to five groups (n=6) namely normal control, negative control, and treatment (50, 250 or 500 mg/kg of MEMM) groups. Colon tissues were harvested for histopathological analysis and endogenous antioxidant system determination. MEMM was also subjected to HPLC analysis. Findings showed that MEMM significantly (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|