The Potential Use of PGC-1α and PGC-1β to Protect the Retina by Stimulating Mitochondrial Repair

Autor:	John D. Ash, Carolina Abrahan
Rok vydání:	2015
Předmět:	0301 basic medicine Retinal degeneration Programmed cell death Mitochondrion Biology medicine.disease Neuroprotection Cell biology 03 medical and health sciences 030104 developmental biology Mitochondrial biogenesis Coactivator medicine Organelle biogenesis Transcription factor
Zdroj:	Retinal Degenerative Diseases ISBN: 9783319171203
DOI:	10.1007/978-3-319-17121-0_53
Popis:	Damage to mitochondria is a common mechanism of cell death in inherited neurodegenerative disorders. Therefore, mitochondrial protection and mitochondrial repair are promising strategies to induce retinal neuroprotection. Peroxisome proliferator-activated receptor γ coactivator-α (PGC-1α) and β (PGC-1β) are transcriptional coactivators that are the main regulators of mitochondrial biogenesis. We propose that PGC-1α and PGC-1β could play a role in regulating retina cell survival, and may be important therapeutic targets to prevent retinal degeneration.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::41f582a94b1553b09aff18dbf138d408 https://doi.org/10.1007/978-3-319-17121-0_53 Zobrazit plný text záznamu