GABA A receptors and inhibitory neurotransmission in the amygdalar complex
| Autor: | Joseph W. Lynch, Pankaj Sah, Madhusoothanan Bhagavathi Perumal |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Physiology GABAA receptor Chemistry Protein subunit Neurotransmission Emotional processing Inhibitory postsynaptic potential 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Signalling Physiology (medical) GABAergic Receptor Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Current Opinion in Physiology. 2:58-64 |
| ISSN: | 2468-8673 |
| DOI: | 10.1016/j.cophys.2018.01.003 |
| Popis: | The amygdalar complex (AC) located in the mid-temporal lobe plays a key role in processing emotionally salient information to generate appropriate behavioural output. Inhibitory signalling mediated by GABAergic neurons, and acting through GABAARs within the AC, potently modulates local processing and output of the AC. Disorders of emotional processing such as anxiety and stress, engage the AC, and some of the treatments for these disorders are thought to act via GABAARs receptors in AC. Here we review GABAergic circuits in the AC, the distribution of GABAARs and their putative functional roles through subunit specific GABAARs signalling. |
| Databáze: | OpenAIRE |
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