A simple procedure for the solid phase synthesis of unsymmetrically functionalised diamides from symmetric diacids

Autor:	Amal Wahhab, Johann Leban
Rok vydání:	1999
Předmět:	Solid-phase synthesis Chemistry Organic Chemistry Drug Discovery Polymer chemistry Organic chemistry Amine gas treating Cleavage (embryo) Biochemistry
Zdroj:	Tetrahedron Letters. 40:235-238
ISSN:	0040-4039
DOI:	10.1016/s0040-4039(98)02327-2
Popis:	The solid phase synthesis of unsymmetrically substituted diamides from symmetric dicar☐ylic acids is described. The process was conducted following these steps: (1) preactivation of the dicar☐ylic acid with BOP, (2) addition to amine resin, (3) reaction with a second amine, and (4) TFA cleavage to afford the desired diamide. Most of the unsymmetric diamides were obtained in >80% purity.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::41e34d00ce9c1cabbc202e53c26e217d https://doi.org/10.1016/s0040-4039(98)02327-2 Zobrazit plný text záznamu Full Text from ScienceDirect