The crystal and molecular structure of 1-(Hexahydro-1H-azepin-1-yl)-3-(p-tolylsulfonyl) Urea: Tolazamide (C14H21N3O3S)

Autor:	Young Hee Yeon, Jung Sun Suh, Chung Hoe Koo, Tokunosuke Watanabe
Rok vydání:	1988
Předmět:	Hydrogen bond Chemistry Organic Chemistry Crystal structure Triclinic crystal system Tolazamide Crystal Crystallography symbols.namesake Drug Discovery medicine symbols Molecular Medicine Molecule van der Waals force Diffractometer medicine.drug
Zdroj:	Archives of Pharmacal Research. 11:74-79
ISSN:	1976-3786 0253-6269
DOI:	10.1007/bf02884772
Popis:	Crystals of tolazamide, C14H21N3O3S, are triclinic, space group PĪ, with cell dimensions ofa=6.355(2),b=9.223(2),c=13.510(3) A, α=101.04(8), β=92.80(5), γ=85.72(6)° and Z=2. Intensities were collected on an automated four-circle diffractometer using graphite-monochromated Cu K α radiations. The structure was solved by direct method and refined by full-matrix least-squares to an R factor of 0.058 for 1184 observed reflections. The molecules are dimerized by the N-H···O hydrogen bonds. There are only van der Waals interactions between these molecular dimers.
Databáze:	OpenAIRE
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