Adipocyte volumes and levels of adipokines in diabetes and obesity
| Autor: | Alpaslan Tuzcu, Mithat Bahceci, Senay Arikan, Sehmus Ozmen, Ramazan Danis, Deniz Gokalp |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
medicine.medical_specialty
Adiponectin business.industry Endocrinology Diabetes and Metabolism Adipokine General Medicine Type 2 diabetes medicine.disease Obesity chemistry.chemical_compound Insulin resistance Endocrinology chemistry Internal medicine Adipocyte Diabetes mellitus Internal Medicine medicine Resistin business hormones hormone substitutes and hormone antagonists |
| Zdroj: | Diabetes & Metabolic Syndrome: Clinical Research & Reviews. 2:253-258 |
| ISSN: | 1871-4021 |
| DOI: | 10.1016/j.dsx.2008.07.001 |
| Popis: | Summary Aim Obesity is a major risk factor for insulin resistance, type 2 diabetes, heart disease, and many other chronic diseases. The factors regulating cytokine production seem to have a role on the determination of adipocyte volume. We aimed to investigate the association of plasma adiponectin and resistin concentrations with adipocyte volumes in obese, diabetic, obese–diabetic and control groups. Methods Plasma adiponectin, resistin and lipid levels and adipocyte volumes were investigated in obese, non-diabetic, non-obese diabetic, obese diabetic and control groups consisting 100 subjects who planned to undergo elective surgery. Differences in clinical or laboratory parameters among groups were compared by using one-way ANOVA test. Chi-square test was used for comparing the frequencies. Results The lipid values in all three groups were higher than the control group. A negative correlation was found between adiponectine levels and adipocyte volumes. When adipocyte volumes were compared with other groups, adipocyte volumes were significantly higher in the obese diabetic group ( p = 0.000). The adipocyte volumes in the obese group were determined to be higher than the control group. Conclusions Although a positive correlation was found between adipocyte volumes and adiponectin in literature, adiponectin concentrations in our study were lower. These conditions can be explained by the effect of insulin resistance on the adiponectin levels in obese diabetic groups. Moreover, adiponectin levels are mostly associated with subcutaneous adipose tissue which may have been less. Resistin levels may play an important role in the development of obesity, insulin resistance and diabetes. |
| Databáze: | OpenAIRE |
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