Detection of bone marrow-derived cells in neointimal thickening in the rat carotid artery by nested polymerase chain reaction

Autor:	Radiukhina Nv, Il'inskaia Op, Antropova IuG, Natalia Kalinina, Eduard Tararak, Mishina Va
Rok vydání:	2008
Předmět:	Neointima Pathology medicine.medical_specialty Intimal hyperplasia Chemistry Carotid arteries medicine.medical_treatment Anatomy medicine.disease medicine.anatomical_structure Smooth muscle Angioplasty medicine Thickening Bone marrow Nested polymerase chain reaction Developmental Biology
Zdroj:	Russian Journal of Developmental Biology. 39:227-231
ISSN:	1608-3326 1062-3604
DOI:	10.1134/s1062360408040048
Popis:	The bone marrow origin of cells involved in neointimal formation after injury of the luminal surface of the vessel was confirmed by highly sensitive nested polymerase chain reaction on isolated vascular wall cells. The model of intimal hyperplasia after balloon angioplasty of the carotid artery in radiation bone marrow chimeras between male and female Wistar rats was used. The Y chromosomes of rat male donors of the bone marrow for irradiated females were used as a marker of bone marrow-derived cells. This approach demonstrated a bone marrow origin of a large fraction of α-actin-positive (smooth muscle) neointimal cells.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::41dee73c1d49f6daf0158f2907ab53f3 https://doi.org/10.1134/s1062360408040048 Zobrazit plný text záznamu Full text from SpringerLink