SAT0346 Clinically meaningful improvement in skin and nail psoriasis in bio-naÏve active psoriatic arthritis patients treated with intravenous golimumab: results through week 24 of the go-vibrant study
| Autor: | Soumya D. Chakravarty, M.E. Husni, A. Kavanaugh, P. J. Mease, D. Parenti, L. Kim, Elizabeth C. Hsia, Kim Hung Lo, S. Kafka, Diane D. Harrison |
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| Rok vydání: | 2018 |
| Předmět: |
030203 arthritis & rheumatology
0301 basic medicine medicine.medical_specialty business.industry Dermatology Life Quality Index medicine.disease Nail psoriasis Golimumab 03 medical and health sciences Psoriatic arthritis 030104 developmental biology 0302 clinical medicine Psoriasis Area and Severity Index Internal medicine Active disease medicine business medicine.drug |
| Zdroj: | Saturday, 16 JUNE 2018. |
| DOI: | 10.1136/annrheumdis-2018-eular.1766 |
| Popis: | Background GO-VIBRANT was a Ph3 trial of IV golimumab (GLM) in adult pts w/active PsA. Objectives To evaluate improvement in skin, nail psoriasis and Dermatology Life Quality Index (DLQI) w/IV GLM. Methods Adult bio-naive PsA pts w/active disease(≥5 swollen and tender joints, CRP ≥0.6 mg/dl, active plaque PsO or documented history, and despite treatment w/csDMARDs and /or NSAIDs)were randomised to IV GLM 2 mg/kg at wks0, 4, and q8wks thereafter or PBO at wks0, 4, 12, and 20 w/crossover to GLM at wk24. Pts w/≥3% body surface area(BSA)PsO at baseline (BL) were assessed using Psoriasis Area and Severity Index(PASI,0–72) 75/90/100% and modified Nail Psoriasis Severity Index(mNAPSI,0–130) at BL, wks14 and 24(in pts w/mNAPSI>0 at BL). DLQI was assessed at BL, wks8, 14 and 24. Results 394 pts(PBO:n=198;GLM:n=196) had ≥3% BSA PsO at BL; 76.5% had mNAPSI >0 at BL(mean 18.6).Pts on GLM achieved a greater PASI75 response vs PBO(59.2% vs 13.6%,p Conclusions As early as wk14, IV GLM demonstrated clinically meaningful improvements in skin PsO irrespective of MTX use and nail PsO. Improvement in DLQI was seen as early as wk8, w/continued improvement at wks14 and 24. Disclosure of Interest P. Mease Grant/research support from: Janssen Research and Development, LLC, M. Husni Grant/research support from: Janssen Research and Development, LLC, S. Chakravarty Employee of: Janssen Scientific Affairs, LLC, S. Kafka Employee of: Janssen Scientific Affairs, LLC, D. Harrison Employee of: Janssen Research and Development, LLC, D. Parenti Employee of: Janssen Scientific Affairs, LLC, L. Kim Employee of: Janssen Research and Development, LLC, K. Lo Employee of: Janssen Research and Development, LLC, E. Hsia Employee of: Janssen Research and Development, LLC, A. Kavanaugh Grant/research support from: Janssen Research and Development, LLC |
| Databáze: | OpenAIRE |
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