High-throughput method for the analysis of venlafaxine in pharmaceutical formulations and biological fluids, using a tris(2,2′-bipyridyl) ruthenium(II)-peroxydisulphate chemiluminescence system in a two-chip device

Autor:	Gouri B. Varma, Fakhr Eldin O. Suliman, Haider A. J. Al Lawati
Rok vydání:	2012
Předmět:	Tris Chromatography Calibration curve Relative standard deviation Biophysics chemistry.chemical_element Serum samples Ruthenium law.invention chemistry.chemical_compound chemistry Chemistry (miscellaneous) law Biological fluids Chemiluminescence
Zdroj:	Luminescence. 28:44-49
ISSN:	1522-7235
DOI:	10.1002/bio.2334
Popis:	A simple, rapid and sensitive chemiluminescent (CL) method for the assay of venlafaxine (VEN) in pharmaceutical formulations and serum samples by a two-chip device is proposed. The method is based on the reaction of this drug with a tris(2,2′-bipyridyl) ruthenium(II)–peroxydisulphate CL system. The optimum chemical conditions for CL emission were investigated. The calibration graph was linear for the concentration range 0.02–8.0 µg/mL. The detection and quantification limits were found to be 0.006 and 0.018 µg/mL, respectively, while the relative standard deviation (RSD) was
Databáze:	OpenAIRE
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