| Popis: |
Partial synthesis of a variety of minor Colchicum alkaloids, including demecolcine, cornigerine, colchifoline, and phenolic congeners has been accomplished. An X-ray analysis of biologically ‘active' and ‘inactive' representatives showed that they were differently hydrogen-bonded in the solid state, and that for structure-activity studies monomeric presentations might not reveal the most important structural features in these molecules. Affinity labelled colchicine which binds well to tubulin has been prepared and is potentially useful for mapping the colchicine binding site on tubulin. |
