Influence of Sulfanilamide on Mucoid and Smooth-Phase Cultures of Hemolytic Streptococci in Vitro
| Autor: | Philip Hadley, Faith P. Hadley |
|---|---|
| Rok vydání: | 1941 |
| Předmět: | |
| Zdroj: | Journal of Infectious Diseases. 68:246-263 |
| ISSN: | 1537-6613 0022-1899 |
| DOI: | 10.1093/infdis/68.3.246 |
| Popis: | Numerous experiments dealing with the mode of action of sulfanilamide have demonstrated that the chief influence is exerted on the organisms themselves. If this is true three sorts of effect are possible: (1) direct germicidal influence; (2) bacteriostatic influence; and (3) the conditioning of a dissociative transformation, or some related form of modification, of the infecting organisms into a nonvirulent or less virulent state. Knowledge of the action of many incitants to dissociative variation would justify the view that the second and third influences might operate at the same time. These possibilities deal with what might be termed the superficial influences of sulfanilamide and may be examined separately. The present study is not concerned with the actual biochemical reactions or mechanisms that underlie these superficial effects. That aspect is dealt with by other members of our group. Bacteriostasis.-These effects are manifested in vitro in culture mediums containing normal, whole blood, normal serums, sulfanilamide blood and sulfanilamide serums. Also important is the fact that bacteriostatic effects have appeared just as clearly in mediums in which no blood or serum was present. Recovery of growth, however, has often been observed to occur in vitro; and, in vivo, where bacteriostasis also obtains, the exact manner of disappearance of the "inhibited" organisms has not become clear. Some workers have leaned |
| Databáze: | OpenAIRE |
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