The cell wall component lipoteichoic acid of Staphylococcus aureus induces chemokine gene expression in bovine mammary epithelial cells

Autor:	Toshiro Arai, Yoshio Kiku, Fuyuko Tanabe, Kazue Sugawara, Atsushi Watanabe, Eiji Hata, Yuya Nagasawa, Tomomi Ozawa, Tomohito Hayashi, Keiichi Nakajima
Rok vydání:	2016
Předmět:	0301 basic medicine Chemokine General Veterinary Inflammation Chemotaxis Biology Microbiology 03 medical and health sciences 030104 developmental biology Immune system CXCL6 Gene expression medicine biology.protein Lipoteichoic acid Interleukin 8 medicine.symptom
Zdroj:	Journal of Veterinary Medical Science. 78:1505-1510
ISSN:	1347-7439 0916-7250
DOI:	10.1292/jvms.15-0706
Popis:	Staphylococcus aureus (SA) is a major cause of bovine mastitis, but its pathogenic mechanism remains poorly understood. To evaluate the role of lipoteichoic acid (LTA) in the immune or inflammatory response of SA mastitis, we investigated the gene expression profile in bovine mammary epithelial cells stimulated with LTA alone or with formalin-killed SA (FKSA) using cap analysis of gene expression. Seven common differentially expressed genes related to immune or inflammatory mediators were up-regulated under both LTA and FKSA stimulations. Three of these genes encode chemokines (IL-8, CXCL6 and CCL2) functioning as chemoattractant molecules for neutrophils and macrophages. These results suggest that the initial inflammatory response of SA infection in mammary gland may be related with LTA induced chemokine genes.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::41b88ec5f6321ba4e92fb7f18259d714 https://doi.org/10.1292/jvms.15-0706 Zobrazit plný text záznamu