| Popis: |
Background: Diabetes mellitus (DM) is a long-lasting clinical syndrome characterized by raised blood glucose leading to numerous other complications. Objective: To study the phytochemical, anti-hyperglycemic, anti-hyperlipidimic and histopathological effects of methanol extract of Corchorus olitorius cultivated in Iraq against induced type II diabetes in rats. Methods: C. olitorius leaves extracted with 60% methanol then phytochemical analysis done, forty male rats separated into four groups ten in each the first not received any treatment as a normal control, remaining rats were induced diabetes type 2 by 28 days feeding of high fat diet followed by single intraperitoneal injection of streptozotocin 35 mg/kg, ten of them not received treatment served as diabetics, third and fourth groups received oral metformin (MET) 100 mg/kg and C. olitorius methanol extract (COME) 400 mg/kg respectively for 28 days. Blood samples collected at day 29 for biochemical study of lipid profile and glycemic indices as well as assessment of histological effects on pancreatic tissue sections after scarification. Results: C. olitorius methanol extract contains anthraquinons, flavonoids, saponines and steroids. Treatment with MET or COME significantly reduced the elevated levels of fasting blood glucose, glycated hemoglobin A1, homeostasis model assessment of insulin resistance, total cholesterol, triglycerides, low density lipoprotein and very low density lipoprotein, while, enhance the reduced levels of adiponectin and high density lipoprotein, also COME enhanced insulin release. Histopathological picture of pancreatic tissues of COME or MET treated rats improved than diabetics. Conclusion: Methanol extract of C. olitorius cultivated in Iraq has anti-hyperglycemic, insulin releasing and sensitizing, anti-hyperlipidimic and pancreatic tissue protective effects in type 2 diabetic (T2D) rats. |
