Chemoselective one-pot reductive deamination of aryl amines

Autor:	G. Patrick Meier, Otto J. Geoffroy, Thomas A. Morinelli
Rok vydání:	2001
Předmět:	chemistry.chemical_compound Acetic acid chemistry Sodium bisulfite Reagent Aryl Organic Chemistry Drug Discovery Deamination Organic chemistry Sodium nitrite Biochemistry
Zdroj:	Tetrahedron Letters. 42:5367-5369
ISSN:	0040-4039
DOI:	10.1016/s0040-4039(01)01027-9
Popis:	A one-pot deamination of a wide variety of substituted anilines is described. The process involves a diazotization-dediazotization utilizing acetic acid, sodium nitrite, and sodium bisulfite- inexpensive, ‘green’ reagents. The process occurs quickly under mild conditions, tolerates sensitive functionality, and gives products in modest-to-good yields (16–88%).
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::41a55a8a0fee053b8978c1a0e530539f https://doi.org/10.1016/s0040-4039(01)01027-9 Zobrazit plný text záznamu Full Text from ScienceDirect