Benzethonium Chloride Catalyzed one Pot Synthesis of 2,4,5-Trisubstituted Imidazoles and 1,2,4,5-Tetrasubstituted Imidazoles in Aqueous Ethanol As A Green Solvent
| Autor: | R. Joel Karunakaran, D. Parthiban |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Green chemistry
biology 010405 organic chemistry Benzethonium chloride One-pot synthesis Evisa General Chemistry 010402 general chemistry biology.organism_classification 01 natural sciences Biochemistry 0104 chemical sciences Catalysis Solvent chemistry.chemical_compound chemistry GEOBASE FLUIDEX Drug Discovery Environmental Chemistry Organic chemistry |
| Zdroj: | Oriental Journal of Chemistry. 34:3004-3015 |
| ISSN: | 2231-5039 0970-020X |
| Popis: | A simple, efficient procedure has been developed using N-cationic surfactant namely Benzethonium chloride (BzthCl, 10 mol%) as novel catalyst for the synthesis of 2,4,5-trisubstituted imidazoles by condensation of aldehyde, ammonium acetate and benzil using EtOH-H2O (1:1) as a green solvent at 700C. Same reaction condition was applied successfully to demonstrate the synthesis of various 1,2,4,5-tetrasubstitued imidazoles using aromatic amine as fourth component. The use of benzethonium chloride as a catalyst with dual functionality as surfactant and ionic liquid catalyst is the main novelty of described method. The significant feature of this greener protocol includes high product yields, procedural simplicity and lesser reaction time. |
| Databáze: | OpenAIRE |
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