A turn-on Schiff base fluorescent probe for the exogenous and endogenous Fe3+ ion sensing and bioimaging of living cells

Autor:	Hou Lingjie, Yaling Gong, Caifeng Zhang, Liu Tao, Wenting Liang, Jin Li, Chenhua Deng, Shaomin Shuang, Yu Wang
Rok vydání:	2020
Předmět:	chemistry.chemical_classification Schiff base Aqueous solution Chemistry Metal ions in aqueous solution Hydrazone General Chemistry Photochemistry Fluorescence Catalysis Ion chemistry.chemical_compound symbols.namesake Stokes shift Materials Chemistry symbols Proton NMR
Zdroj:	New Journal of Chemistry. 44:19642-19649
ISSN:	1369-9261 1144-0546
Popis:	A Schiff base fluorescent probe, namely naphthalic anhydride – (2-pyridine) hydrazone (NAH), has been synthesized and developed for the highly selective and sensitive monitoring of Fe3+ ions in an aqueous solution and living cells. The enhanced fluorescence emission intensity of NAH has been observed upon the introduction of Fe3+ with a large Stokes shift of 100 nm, and the trace levels of Fe3+ at 38.3 nM can be monitored with no interference from other existing metal ions. Moreover, the recognition mechanism of NAH with Fe3+ has been discussed via ESI-MS, 1H NMR and FT-IR techniques. The binding mode of NAH with Fe3+ is found to be 1 : 1 complex with the binding constants (Ka) of 1.77 × 106 M−1. In addition, NAH has been demonstrated to be nontoxic by cytotoxicity experiments and successfully proved to be a good probe for exogenous and endogenous Fe3+ sensing in living cells.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::41985aa262e25f86e88fb763b50cb294 https://doi.org/10.1039/d0nj04315j Zobrazit plný text záznamu