Veränderungen der Plasmakreatinkinaseaktivität durch Coxsackievirusinfektion bei Mäusen
| Autor: | M. Sprössig, T. Blumóhr, R. Klöcking |
|---|---|
| Rok vydání: | 1974 |
| Předmět: |
chemistry.chemical_classification
medicine.medical_specialty Myocarditis Strain (chemistry) biology Physical exercise Cell Biology General Medicine Coxsackievirus biology.organism_classification medicine.disease Virology Virus Pathology and Forensic Medicine Enzyme Endocrinology chemistry Internal medicine medicine biology.protein Creatine kinase Molecular Biology Creatine kinase activity |
| Zdroj: | Pathobiology. 40:241-250 |
| ISSN: | 1423-0291 1015-2008 |
| DOI: | 10.1159/000162541 |
| Popis: | Experimental virus myocarditis was induced after subjecting 12–14-month-old albino mice (strain AB × A Jax) to physical exercise (swimming), and infection with Coxsackie virus A9 strain Lerner No. 13. Virus could be isolated from the hearts of infected mice. On day 3 post infection, 94%, and on day 6, 91% of the isolates were positive. If compared to non infected mice, the activity of plasma creatine kinase of infected animals rose considerably. It is suggested that the accelerated release of the enzyme from the heart muscle is due to a decrease in cell membrane stability following virus-cell interaction. Whether or not infection and damage of cardiac muscles has taken place can thus be determined by measuring plasma creatine kinase activity. |
| Databáze: | OpenAIRE |
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