Novel β-galactosidase-specific O2-glycosylated diazeniumdiolate probes

Autor:	Alan C. Evans, Zhijie ChuaZ. Chua, Barry J. Bedell, Alexander CzerniewskiA. Czerniewski, D. Scott Bohle, Shadreck Mzengeza
Rok vydání:	2010
Předmět:	chemistry.chemical_compound chemistry Organic Chemistry Oxyde nitrique General Chemistry Molecular mri Conjugated system Combinatorial chemistry Catalysis Nitric oxide
Zdroj:	Canadian Journal of Chemistry. 88:969-980
ISSN:	1480-3291 0008-4042
DOI:	10.1139/v10-087
Popis:	Three β-galactosidase-specific nitric-oxide-releasing diazeniumdiolate conjugated probes were prepared as a prelude to studies of new potential molecular MRI imaging agents. A glycosylated derivative, 2e, designed to be trafficked across cell membranes, was also prepared. We report, in detail, the synthesis and characterization of these probes. In addition, the release of diazeniumdiolate from the probes by β-galactosidase-catalyzed hydrolysis was used to estimate their efficacy as serum-stable, specific NO donors.
Databáze:	OpenAIRE
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