Evaluation of anticonvulsant activity of amlodipine in albino rats

Autor:	Y. Venkata Rao, B Roopa, M Janardhan
Rok vydání:	2017
Předmět:	Drug Phenytoin business.industry media_common.quotation_subject medicine.medical_treatment Low dose Dose dependence Pharmacology Experimental animal Anticonvulsant Combination group Medicine Amlodipine business media_common medicine.drug
Zdroj:	International Journal of Basic & Clinical Pharmacology. 6:664
ISSN:	2279-0780 2319-2003
DOI:	10.18203/2319-2003.ijbcp20170833
Popis:	Background: The objective of the study was to evaluate the anticonvulsant activity of amlodipine in albino rats.Methods: Anticonvulsant activity of amlodipine was done in three graded doses (1 mg/kg, 2 mg/kg, 4 mg/kg), and combination group with low dose of amlodipine (1 mg/kg) and standard drug (phenytoin) in maximal electroshock seizures (MES) experimental animal model.Results: Amlodipine in dose of 2, 4 mg/kg showed dose dependent significant anticonvulsant effect and combination of low dose amlodipine and low dose of standard drug also showed significant anticonvulsant effect in MES model.Conclusions: Amlodipine is having anticonvulsant activity and also potentiated the anticonvulsant effect of phenytoin in MES model.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::418f375a0554a45bc50df693048e63e8 https://doi.org/10.18203/2319-2003.ijbcp20170833 Zobrazit plný text záznamu