Synthesis of 2- or 4-Seleno Analogues of dUMP and FdUMP, and the Corresponding Nucleosides. Interactions with Mammalian Tumour Thymidylate Synthase of the Selenonucleotides and Inhibition of Tumor Cell Growth by the Selenonucleosides

Autor:	Katarzyna Wyszynska, Tadeusz Kulikowski, Agnieszka Miazga, Zbigniew Zieliński, Krzysztof Felczak, Barbara Golos, Wojciech Rode, Joanna Ciesla
Rok vydání:	2002
Předmět:	chemistry.chemical_classification Chemotherapy biology Cell growth medicine.medical_treatment education Substrate (chemistry) Tumor cells Methylation complex mixtures Thymidylate synthase Molecular biology Enzyme chemistry Biochemistry biology.protein medicine Nucleoside
Zdroj:	Chemistry and Biology of Pteridines and Folates ISBN: 9781461353171
DOI:	10.1007/978-1-4615-0945-5_79
Popis:	Thymidylate synthase (EC 2.1.1.45), a target enzyme in chemotherapy, catalyzes the N5,10-methylenetetrahydrofolate-dependent C(5) methylation of dUMP. In search of its inhibitors, interactions were compared of new substrate analogues, 4-seleno-dUMP (4-Se-dUMP), 2-seleno-5-fluoro-dUMP (2-Se-FdUMP) and 4-seleno-5-fluoro-dUMP (4-Se-FdUMP), with two thymidylate synthase forms differing in sensitivities towards FdUMP inhibition, isolated from parental and FdUrd-resistant L1210 cell lines (1). The nucleoside forms of the analogues were tested as mouse leukemia L5178Y cell growth inhibitors.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::41885f0daf8a1c1ace077c09bdf49812 https://doi.org/10.1007/978-1-4615-0945-5_79 Zobrazit plný text záznamu