Vitamin B12 deficiency in patients with type 2 diabetes on metformin therapy
| Autor: | Adela Hussien Absat, Eman Zaid, Aisha Elsagier |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
medicine.medical_specialty
endocrine system diseases business.industry Insulin medicine.medical_treatment nutritional and metabolic diseases Type 2 Diabetes Mellitus Type 2 diabetes 030204 cardiovascular system & hematology medicine.disease Gastroenterology Metformin 03 medical and health sciences 0302 clinical medicine Endocrinology Peripheral neuropathy Diabetes mellitus Internal medicine medicine In patient 030212 general & internal medicine Vitamin B12 business medicine.drug |
| Zdroj: | Ibnosina Journal of Medicine and Biomedical Sciences. :72-75 |
| ISSN: | 1947-489X |
| DOI: | 10.4103/1947-489x.210114 |
| Popis: | Background: Vitamin B12 deficiency can cause peripheral neuropathy. Metformin use is associated with vitamin B12 deficiency. Objective: To define the prevalence of vitamin B12 deficiency in patients with type 2 diabetes mellitus (T2DM) and its possible relation to metformin therapy. Patients and Methods : A cross-sectional study of T2DM patients on chronic metformin therapy was conducted at Benghazi Diabetic Center during 2011. Demographic data, type, and duration of treatment reported adherence, vitamin B treatment was documented. History and examination for evidence of peripheral neuropathy were documented. Serum vitamin B12 levels were measured (reference value 159-1000 pg/ml). Results: 500 patients were included of whom175 were males (35%). Mean (SD) age was 58.6 ± 9.9 years and duration of diabetes 13.6 ± 8.4 years. Of these 358 (71.8%) were on insulin and metformin’ 93(18.6%) on sulphonylureas and metformin, 26(5.2%) were on insulin and sulphonylurea and metformin triple combination, and 22 (4.4%) were on metformin only. Mean serum B12 level for all patients was 439 ± 212 pg/ml with males having significantly higher levels than females (512 ± 226 SD, 399± 193; p=0.001). Vitamin B12 levels were |
| Databáze: | OpenAIRE |
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