961-P: Efficacy and Safety of Once-Weekly Semaglutide vs. Once-Daily Sitagliptin as Add-On to Metformin in Subjects with Type 2 Diabetes (SUSTAIN China MRCT): A 30-Week Double-Blind, Phase 3a, Randomised Trial
| Autor: | Linong Ji, Yufeng Li, Freddy Goldberg Eliaschewitz, Ming Liu, Trine V. Skjoeth, Yiming Li, Soeren Rasmussen, Ning Zu, Guoyue Yuan, Soo Lim, Yu-Yao Huang, Dong Xiaolin |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty business.industry Endocrinology Diabetes and Metabolism Semaglutide 030209 endocrinology & metabolism Type 2 diabetes medicine.disease Metformin Clinical trial Double blind 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Weight loss Sitagliptin Internal medicine Internal Medicine Clinical endpoint medicine medicine.symptom business medicine.drug |
| Zdroj: | Diabetes. 69 |
| ISSN: | 1939-327X 0012-1797 |
| DOI: | 10.2337/db20-961-p |
| Popis: | A total of 868 subjects of which 70% were Chinese and 13% Korean were randomised to once-weekly subcutaneous semaglutide 0.5 mg (n=288), 1.0 mg (n=290) or sitagliptin 100 mg (n=290) in a multiregional clinical trial. Both doses of semaglutide were superior to sitagliptin in reducing HbA1c (primary endpoint, Figure 1) and body weight (Table 1) after 30 weeks of treatment. The odds for achieving target HbA1c, weight loss of ≥5% or ≥10% and a composite endpoint were all significantly higher with both semaglutide doses compared to sitagliptin (Table 1). The safety profile of semaglutide was consistent with the previously established profile. Consistent efficacy and safety findings were seen in the Chinese population. Disclosure L. Ji: None. D. Xiaolin: None. F. Eliaschewitz: Advisory Panel; Self; AstraZeneca, Novo Nordisk A/S, Sanofi-Aventis. Research Support; Self; Bayer AG, GlaxoSmithKline plc., Novo Nordisk A/S, Sanofi-Aventis. Speaker’s Bureau; Self; Eli Lilly and Company. Y. Li: None. Y. Li: None. S. Lim: None. M. Liu: None. N. Zu: Employee; Self; Novo Nordisk A/S. S. Rasmussen: Employee; Self; Novo Nordisk A/S. T.V. Skjoeth: Employee; Self; Novo Nordisk A/S. G. Yuan: None. Y. Huang: None. Funding Novo Nordisk A/S |
| Databáze: | OpenAIRE |
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