Design and In-Vitro Evaluation of Nicorindil Biphasic Drug Delivery System for Angina Pectoris
| Autor: | R. G. Kulkarni, H. B. Bansode, O. S. Shende, P. B. Gurav |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Croscarmellose sodium
Drug medicine.medical_specialty Chromatography media_common.quotation_subject Phosphate buffered saline In vitro chemistry.chemical_compound chemistry Internal medicine Drug delivery medicine Cardiology Sustained Release Tablet Immediate release Nicorandil medicine.drug media_common |
| Zdroj: | Techno-Societal 2016 ISBN: 9783319535555 |
| DOI: | 10.1007/978-3-319-53556-2_67 |
| Popis: | Biphasic tablet system made of immediate and sustained release tablet core was prepared by direct compression. The outer layer was formulated to release of drug in very short time, while the mini-tablets provided a sustained passion of drug release. Immediate release component comprised of croscarmellose sodium (5%), while mini-tablet was formulated using different concentration of Olibanum gum. The in vitro drug release profile from these tablets showed desired biphasic release behavior. The Nicorandil contained in immediate release component was dissolved within 2 min, whereas drug in mini-tablets was released at different times, depending on the composition of mini-tablets. Dissolution profile was studied in the medium 0.1 N HCl for first 1 h, then Phosphate Buffer Saline pH 6.8 for remaining period of time. TSP and Olibanum gum core was suitable for providing drug release over 7 h time period. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|