Beneficial effect of carboxylic acid additives on the Pd-catalyzed intramolecular N-arylation of 2-amino-3-(2-chlorophenylsulfonyl)pyrroles

Autor:	Chad E. Stephens, Perounsack X. Moon
Rok vydání:	2013
Předmět:	chemistry.chemical_classification Carboxylic acid Organic Chemistry Phenylacetic acid Ring (chemistry) Biochemistry Medicinal chemistry Catalysis Acetic acid chemistry.chemical_compound chemistry Intramolecular force Yield (chemistry) Drug Discovery Tricyclic
Zdroj:	Tetrahedron Letters. 54:6226-6229
ISSN:	0040-4039
DOI:	10.1016/j.tetlet.2013.09.011
Popis:	Carboxylic acid additives have been shown to significantly improve the yield of the Pd-catalyzed intramolecular N-arylation of 2-aminopyrroles containing a 2-chlorophenylsulfonyl group at the 3-position to give a novel tricyclic ring system. Pivalic and phenylacetic acid provided the best yield enhancement, while acetic acid showed moderate enhancement. Other acids showed limited to no enhancement or even a detrimental effect on the reaction.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::416348c762740c680e519293fcaab4d9 https://doi.org/10.1016/j.tetlet.2013.09.011 Zobrazit plný text záznamu Full Text from ScienceDirect