A Convenient Solid Phase Synthesis of Disubstituted Guanidines

Autor:	K. R. A. Samankumara Sandanayake, Senake Perera, Nicholas J. Ede
Rok vydání:	2004
Předmět:	chemistry.chemical_compound Solid-phase synthesis chemistry Yield (chemistry) Organic Chemistry Drug Discovery Organic chemistry Urea derivatives Cleavage (embryo) Guanidine Combinatorial chemistry Isocyanate Computer Science Applications
Zdroj:	QSAR & Combinatorial Science. 23:655-661
ISSN:	1611-0218 1611-020X
DOI:	10.1002/qsar.200420020
Popis:	TMI-isocyanate SynPhaseTM lanterns have been used in the convenient synthesis of a disubstituted guanidine library. Support-bound isocyanate was reacted with primary amines and the resulting urea derivatives were dehydrated to yield the corresponding support-bound carbodiimides. The carbodiimides were reacted with primary, secondary or anilinic amines to form the corresponding guanidines. Convenient traceless cleavage of the products from the solid phase with 25% TFA/DCM gave the corresponding guanidines in good yield and good to excellent purity.
Databáze:	OpenAIRE
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