Stereotaxic intrastriatal implantation of human retinal pigment epithelial (hRPE) cells attached to gelatin microcarriers: a potential new cell therapy for Parkinson’s disease

Autor:	Natividad P. Stover, Alfred W. Schweikert, Ray L. Watts, C. R. Honey, Michael Cornfeldt, R. A. E. Bakay, Thyagarajan Subramanian, Cathy D. Raiser, Richard C. Allen, D. Doudet
Rok vydání:	2003
Předmět:	Pathology medicine.medical_specialty Retina Retinal pigment epithelium Parkinson's disease medicine.medical_treatment Dopaminergic Microcarrier Immunosuppression Retinal Biology medicine.disease Cell therapy chemistry.chemical_compound medicine.anatomical_structure chemistry medicine Neuroscience
Zdroj:	Advances in Research on Neurodegeneration ISBN: 9783211839072
Popis:	Human retinal pigment epithelial (hRPE) cells are dopaminergic support cells in the neural retina. Stereotaxic intrastriatal implantation of hRPE cells attached to gelatin microcarriers (Spheramine®) in rodent and non-human primate models of Parkinson’s disease (PD) produces long term amelioration of motor and behavioral deficits, with histological and PET evidence of cell survival without immunosuppression. Long-term safety in cynomologous monkeys has also been demonstrated.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::413a614bfa1bdc81aabdd58dbf5de532 https://doi.org/10.1007/978-3-7091-0643-3_14 Zobrazit plný text záznamu