Endogenous Cortisol Response in Infants with Respiratory Distress Syndrome

Autor:	Neşide Çetin, Bahri Elmas, Ömer Çetişli
Rok vydání:	2016
Předmět:	Decreased stress Fetus 030219 obstetrics & reproductive medicine Respiratory distress business.industry Physiology Gestational age Endogeny General Medicine Fight-or-flight response 03 medical and health sciences 0302 clinical medicine 030225 pediatrics Medicine Gestation business Cortisol level
Zdroj:	Sakarya Medical Journal. 6:124-130
ISSN:	2146-409X 2146-2585
Popis:	Objective Respiratory distress syndrome (RDS) is the most important cause of morbidity and mortality in premature infants. Although gestational age is the most important factor for development of RDS, some maternal and fetal factors are also effective in the development. Steroids are known to stimulate the production and secretion of surfactant at birth thru of c-AMP (cylic adenosin monophospahate) pathway. In some premature infants, RDS does not develop. This suggests the possibility that postnatal course of the disease might be associated with endogenous stress response in the baby. In this study, endogenous cortisol response to stress was investigated in newborns with RDS. Materials and Methods: Cortisol levels were studied 2nd -8th hours after birth and the second day in newborns with gestational ages varying from 28th to 35th weeks. Twenty newborns were associated with RDS, 19 newborns with mild respiratory distress, and 25 healthy newborns. Results: The average first cortisol levels in RDS group (52.90 ± 57.47 mg/dl) were significantly higher than the control group (29.51±13: 52 mg/ dl; P
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::413450abf2034d3c70b19f81ae918ed1 https://doi.org/10.5505/sakaryamedj.2016.45577 Zobrazit plný text záznamu