Single Dose Crossover Study to Evaluate the Absolute Bioavailability of a Sustained-Release Formulation of Bunazosin (E1015) in Healthy Male Volunteers

Autor:	Jiro Hasegawa, Horst-Jürgen Heuer, Nobumichi Morishita, Yoshiro Tomono
Rok vydání:	1993
Předmět:	Bunazosin Intravenous drug business.industry Pharmacology toxicology General Medicine Pharmacology Crossover study Pharmacokinetics Anesthesia Healthy volunteers Medicine Pharmacology (medical) business medicine.drug Absolute bioavailability
Zdroj:	Drug Investigation. 6:5-9
ISSN:	1179-1918 0114-2402
DOI:	10.1007/bf03259419
Popis:	An open-label randomised crossover study was undertaken to investigate the pharmacokinetics of intravenous bunazosin, and to determine the absolute bioavailabilities of the standard and sustained-release tablet formulations of the drug. 12 healthy volunteers received a 10-minute intravenous infusion of bunazosin 1mg, 2 conventional sugar-coated bunazosin 1mg tablets, and a sustained-release bunazosin 6mg tablet under fasting conditions. Plasma bunazosin concentrations declined in a biexponential manner following intravenous drug administration, and similar terminal elimination half-lives (≈ 2 hours) were observed with intravenous bunazosin and the conventional tablet. The absolute bioavailabilities of the conventional and sustained-release tablet formulations of bunazosin were 44.1 ± 7.7 and 44.6 ± 10.6%, respectively (mean ± SD).
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::4133d4e5707d229ada0930aa41c3f933 https://doi.org/10.1007/bf03259419 Zobrazit plný text záznamu Full text from SpringerLink