Humoral and cellular rejection after combined liver-kidney transplantation in low immunologic risk recipients

Autor:	Jean Villard, Sylvie Ferrari-Lacraz, Emiliano Giostra, Gilles Mentha, Karine Hadaya, Jean-François Bolle, Laura Rubbia-Brandt, Jean-Pierre Venetz, Nicola Marangon, Pietro Majno, Solange Moll
Rok vydání:	2008
Předmět:	Transplantation Kidney biology business.industry medicine.medical_treatment Human leukocyte antigen Histocompatibility Testing Liver transplantation medicine.disease medicine.anatomical_structure ABO blood group system Immunology medicine biology.protein Antibody business Kidney transplantation
Zdroj:	Transplant International. 22:242-246
ISSN:	0934-0874
DOI:	10.1111/j.1432-2277.2008.00775.x
Popis:	Combined liver-kidney transplantation is considered a low risk for immunologic complication. We report an unusual case of identical ABO liver-kidney recipient without preformed anti-human leukocyte antigen (HLA) antibodies, transplanted across a T- and B-cell-negative cross-match and complicated by early acute humoral and cellular rejection, first in the liver then in the kidney. While analyzing the immunologic complications in our cohort of 12 low-risk combined liver-kidney recipients, only one recipient experienced a rejection episode without detection of anti-HLA antibody over time. Although humoral or cellular rejection is rare after combined kidney-liver transplantation, our data suggest that even in low-risk recipients, the liver does not always systematically protect the kidney from acute rejection. Indeed, the detection of C4d in the liver should be carefully followed after combined liver-kidney transplantation.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::4121521dac86297e285b228fb046ea2a https://doi.org/10.1111/j.1432-2277.2008.00775.x Zobrazit plný text záznamu Plný text