Effectiveness of selenium supplementation in children with autoimmune thyroiditis
| Autor: | Yuni Hisbiyah, Anang Endaryanto, Bagoes Setyoboedi, Nur Rochmah, Muhammad Faizi, Citrawati Dyah Kencono Wungu, Qurrota Ayuni Novia Putri |
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| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | International journal of health sciences. :1395-1410 |
| ISSN: | 2550-696X 2550-6978 |
| Popis: | Deficiencies of Selenium (Se) is correlated with the risk and onset of autoimmune thyroid disease (AITD). The aim of this study was to determine the association between Se supplementation and AITD. Methods: Electronic data searches of 4 databases were performed. We assessed the included studies using PRISMA for protocol assurance. Five studies met our inclusion criteria and were analyzed. The predictor covariate in the present study was Se administration. The outcome measures were levels of thyroid peroxidase antibodies (TPO-Ab), thyroglobulin antibody (Tg-Ab), free thyroxine (fT4), and thyroid volume. Results: Of the five studies that met the inclusion criteria, one randomized controlled trial (RCT) was included in the qualitative review, whereas four quasi-experimental studies were included in the meta-analysis. The results showed that Se supplementation significantly reduced TPO-Ab levels (MD 90.85; 95% CI 61.71–120.00; p |
| Databáze: | OpenAIRE |
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