dextro-Naloxone or levo-naloxone reverses the attenuation of morphine antinociception induced by lipopolysaccharide in the mouse spinal cord via a non-opioid mechanism

Autor:	Maia Terashvili, Leon F. Tseng, Hsiang-en Wu, Han-Sen Sun, Caleb W. Cheng
Rok vydání:	2006
Předmět:	Lipopolysaccharide Chemistry General Neuroscience Stimulation (+)-Naloxone Pharmacology Spinal cord chemistry.chemical_compound Mouse Spinal Cord medicine.anatomical_structure Opioid Anesthesia medicine Morphine Neuroglia medicine.drug
Zdroj:	European Journal of Neuroscience. 24:2575-2580
ISSN:	0953-816X
DOI:	10.1111/j.1460-9568.2006.05144.x
Popis:	Glial stimulation by intrathecal injection of lipopolysaccharide (LPS) attenuated the tail-flick inhibition produced by morphine given intrathecally in the spinal cord of the male CD-1 mice. The phenomenon has been defined as antianalgesia. The effects of dextro-naloxone or levo-naloxone on the attenuation of morphine-produced tail-flick inhibition induced by LPS were then studied. Pretreatment with dextro-naloxone or levo-naloxone reversed the attenuation of the morphine-produced tail-flick inhibition induced by LPS. Pretreatment with dextro-naloxone or levo-naloxone alone did not affect the morphine-produced tail-flick inhibition. It is concluded that dextro-naloxone and levo-naloxone block the LPS-induced antianalgesia against morphine antinociception via a non-opioid mechanism.
Databáze:	OpenAIRE
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