Shining a Light on the Mechanisms of Sleep for Memory Consolidation
| Autor: | Rockelle S. Guthrie, Yesenia Cabrera, Michelle A. Frazer, Gina R. Poe |
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| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Pulmonary and Respiratory Medicine Consolidation (soil) Hippocampus Sleep spindle Optogenetics Sleep in non-human animals Non-rapid eye movement sleep 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Neurology Memory consolidation Neurology (clinical) Psychology Motor learning Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Current Sleep Medicine Reports. 7:221-231 |
| ISSN: | 2198-6401 |
| Popis: | Purpose of review This paper reviews all optogenetic studies that directly test various sleep states, traits, and circuit-level activity profiles for the consolidation of different learning tasks. Recent findings Inhibiting or exciting neurons involved either in the production of sleep states or in the encoding and consolidation of memories reveals sleep states and traits that are essential for memory. REM sleep, NREM sleep, and the N2 transition to REM (characterized by sleep spindles) are integral to memory consolidation. Neural activity during sharp-wave ripples, slow oscillations, theta waves, and spindles are the mediators of this process. Summary These studies lend strong support to the hypothesis that sleep is essential to the consolidation of memories from the hippocampus and the consolidation of motor learning which does not necessarily involve the hippocampus. Future research can further probe the types of memory dependent on sleep-related traits and on the neurotransmitters and neuromodulators required. |
| Databáze: | OpenAIRE |
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