Influence of sodium lauryl sulphate on the in vitro percutaneous absorption of compounds with different lipophilicity

Autor:	M. J. Morant, Octavio Díez-Sales, M Herráez-Domı́nguez, A. López, J. Borrás-Blasco
Rok vydání:	1997
Předmět:	Chromatography integumentary system Permeability (electromagnetism) Chemistry Sodium lauryl sulphate Lipophilicity Percutaneous absorption medicine Pharmaceutical Science Salicylamide In vitro Pentoxifylline medicine.drug
Zdroj:	European Journal of Pharmaceutical Sciences. 5:15-22
ISSN:	0928-0987
DOI:	10.1016/s0928-0987(96)00184-4
Popis:	The effects of sodium lauryl sulphate (SLS) at different concentrations on the “in vitro” percutaneous absorption of a number of compounds (5-fluorouracil, antipyrine, pentoxifylline, salicylamide, 4-ethylaniline, 4-n-butylaniline and indomethacin) with a wide range of lipophilicity values (log POCT from −0.95 to 4.42) through rat skin were analysed. After pretreatment of the skin with SLS (1% and 5%, w/w) the permeability coefficients increased only for compounds having a log POCT
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::410ce859ca97e19a6a72bbd409894c00 https://doi.org/10.1016/s0928-0987(96)00184-4 Zobrazit plný text záznamu Full Text from ScienceDirect