In vitro magnetic resonance spectroscopy of healthy and neoplastic brain tissues
| Autor: | Alessandro Bertoluzza, G. Barbarella, M. R. Tosi, Giancarlo Fini, Vitaliano Tugnoli, R. Ricci |
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| Rok vydání: | 1999 |
| Předmět: |
Endothelial proliferation
Molecular composition medicine.diagnostic_test Chemistry Metabolic heterogeneity Metabolite Organic Chemistry Anaplastic oligodendroglioma Magnetic resonance imaging Nuclear magnetic resonance spectroscopy In vitro nervous system diseases Analytical Chemistry Inorganic Chemistry chemistry.chemical_compound Nuclear magnetic resonance medicine neoplasms Spectroscopy |
| Zdroj: | Journal of Molecular Structure. :365-369 |
| ISSN: | 0022-2860 |
| DOI: | 10.1016/s0022-2860(98)00679-6 |
| Popis: | In this study an in vitro Magnetic Resonance Spectroscopic characterization of water soluble metabolites and the lipid fraction obtained from 31 tumors (14 glioblastomas, 3 anaplastic astrocitomas, 2 anaplastic oligodendrogliomas, 2 oligodendrogliomas and 10 meningiomas) is reported. The 1H MR spectrum of normal brain tissue is also shown, it is characterized by a low Cho/Cr signal intensity ratio and an intense NAA resonance. The regional metabolic heterogeneity of glioblastomas is documented. For these tumors, specific molecular composition by MRS cannot be defined. Oligodendrogliomas and anaplastic oligodendrogliomas showed typical Cho/Cr and Ala/Cr metabolite ratios. The degree of histological endothelial proliferation of the malignant astrocitomas and oligodendrogliomas was correlated to the presence of Cholesteryl esters in the 13C Magnetic Resonance spectrum of the lipid fraction obtained from these tumors. Meningiomas are mainly characterized by high Cho/Cr and Ala/Cr ratios. |
| Databáze: | OpenAIRE |
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