A straightforward and versatile approach to the synthesis of 1,4,5-trisubstituted 1,2,3-triazoles from alkyl halides via a one-pot, three-component reaction

Autor:	Carlos A. González-González, Aydeé Fuentes-Benítes, Davir González-Calderón, José G. Aguirre-de Paz, Carlos González-Romero
Rok vydání:	2015
Předmět:	Reaction conditions chemistry.chemical_classification chemistry.chemical_compound chemistry Component (thermodynamics) Organic Chemistry Drug Discovery Sodium azide Halide Biochemistry Combinatorial chemistry Cycloaddition Alkyl
Zdroj:	Tetrahedron Letters. 56:1713-1715
ISSN:	0040-4039
DOI:	10.1016/j.tetlet.2015.02.049
Popis:	The preparation of 1,4,5-trisubstituted 1,2,3-triazoles by the coupling of three components (alkyl halides, sodium azide, and active ketones) through an azide–enolate [3+2] cycloaddition (Dimroth cycloaddition) has been developed for the first time. A wide variety of halides (including chlorides, bromides, and iodides as well as primary and secondary derivatives) have demonstrated the versatility of this method, which is based on a one-pot system under mild reaction conditions.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::40fddbb06d7554e7a2c48e7b57557cba https://doi.org/10.1016/j.tetlet.2015.02.049 Zobrazit plný text záznamu Full Text from ScienceDirect