Silver-Catalyzed Hydroamination: Synthesis of N-Bridgehead Pyrroles, Incorporating a Protection-Deprotection Strategy for Preparation of Cyclic Secondary Vinylogous Carbamates

Autor:	Martin C. Dovey, David Gravestock, Ross S. Robinson
Rok vydání:	2005
Předmět:	Chemistry Yield (chemistry) Intramolecular force Microwave irradiation Sequence (biology) General Medicine Hydroamination Combinatorial chemistry Pyrrole derivatives Catalysis
Zdroj:	ChemInform. 36
ISSN:	1522-2667 0931-7597
DOI:	10.1002/chin.200522106
Popis:	N-Bridgehead pyrroles are efficiently prepared from cyclic secondary vinylogous carbamates using a two-step sequence. This sequence involves C-propargylation followed by a silver-catalyzed intramolecular hydroamination. Hydroamination is brought about using microwave irradiation and affords the desired N-bridgehead pyrroles rapidly and in good yield. Cyclic secondary vinylogous carbamates are prepared using a mild, economical procedure. (© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2005)
Databáze:	OpenAIRE
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