Effects of omega-3 polyunsaturated fatty acids administration on vascular function, inflammatory and fibrinolytic status in adults with metabolic syndrome
| Autor: | Gerasimos Siasos, Eleni Kokkou, Antigoni Miliou, E Oikonomou, Aris Plastiras, K. Maniatis, Dimitrios Tousoulis, C. Stefanadis, Marina Zaromitidou, Alexios Verveniotis |
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| Rok vydání: | 2013 |
| Předmět: |
chemistry.chemical_classification
medicine.medical_specialty Endothelium business.industry medicine.disease Placebo chemistry.chemical_compound Endocrinology medicine.anatomical_structure chemistry Internal medicine Plasminogen activator inhibitor-1 medicine Arterial stiffness lipids (amino acids peptides and proteins) Metabolic syndrome Cardiology and Cardiovascular Medicine business Pulse wave velocity Fibrinolytic agent Polyunsaturated fatty acid |
| Zdroj: | European Heart Journal. 34:P4296-P4296 |
| ISSN: | 1522-9645 0195-668X |
| DOI: | 10.1093/eurheartj/eht309.p4296 |
| Popis: | Purpose: Metabolic syndrome (MetS) is associated with impaired vascular function. Aim of the present study was to evaluate the effects of omega-3 polyunsaturated fatty acids (PUFAs) supplementation on endothelial function, arterial stiffness, inflammatory and fibrinolytic process in subjects with MetS. Methods: We studied the effect of a 12 weeks oral treatment with 2gr/day of omega-3 PUFAs in 29 (15 male) subjects (mean age 44±12 years) with MetS on three occasions (day 0: baseline, day 28 and day 84). The study was carried out on two separate arms (PUFAs and placebo), according to a randomized, placebo-controlled, double-blind, cross-over design. The diagnosis of MetS was based on the guidelines of Adult Treatment Panel III definition. Endothelial function was evaluated by flow-mediated dilation (FMD) of the brachial artery. Carotid-femoral pulse wave velocity (PWV) was measured as an index of aortic stiffness. Serum levels of interleukin-6 (IL-6) and plasminogen activator inhibitor-1 (PAI-1) were measured by ELISA. Fasting serum lipid levels were measured using chromatographic enzymic method. Results: Treatment with PUFAs resulted in a significant increase in FMD and PWV (p |
| Databáze: | OpenAIRE |
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