Compact and Integrated Approach for Advanced End-to-End Production, Purification, and Aqueous Formulation of Lidocaine Hydrochloride
| Autor: | Eve Revalor, Torsten Stelzer, Klavs F. Jensen, Jean-Christophe Monbaliu, Allan S. Myerson, Nopphon Weeranoppanant |
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| Rok vydání: | 2016 |
| Předmět: |
Active ingredient
Materials science Aqueous solution Daily production Chromatography 010405 organic chemistry Continuous flow Organic Chemistry Extraction (chemistry) Lidocaine Hydrochloride Integrated approach 010402 general chemistry 01 natural sciences 0104 chemical sciences law.invention law Physical and Theoretical Chemistry Crystallization |
| Zdroj: | Organic Process Research & Development. 20:1347-1353 |
| ISSN: | 1520-586X 1083-6160 |
| DOI: | 10.1021/acs.oprd.6b00165 |
| Popis: | A compact, fully integrated, and automated system is developed for end-to-end production, purification, and formulation of the active pharmaceutical ingredient (API) lidocaine hydrochloride, a widely used local anesthetic. The purification strategy includes appropriate combination of extraction, reactive crystallization, and antisolvent cooling crystallization that enables the production of lidocaine hydrochloride formulated solution, for topical application meeting US Pharmacopeia (USP) standards. On the basis of the optimal yield observed in each step, the system sustains a daily production of 810 doses (dosage strength = 20 mg mL–1, i.e., 2% formulation in commercial denomination). |
| Databáze: | OpenAIRE |
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