ChemInform Abstract: Structure-Based Design of Peptidomimetic Ligands of the Grb2-SH2 Domain

Autor:	J. SCHOEPFER, B. GAY, G. CARAVATTI, C. GARCIA-ECHEVERRIA, H. FRETZ, J. RAHUEL, P. FURET
Rok vydání:	2010
Předmět:	chemistry.chemical_classification biology Stereochemistry Phosphopeptide Peptidomimetic Peptide Sequence (biology) General Medicine SH2 domain Domain (software engineering) chemistry biology.protein Structure based GRB2 biological phenomena cell phenomena and immunity
Zdroj:	ChemInform. 30
ISSN:	1522-2667 0931-7597
DOI:	10.1002/chin.199906177
Popis:	We have designed and synthesized a (3-aminomethyl-phenyl)-urea scaffold to mimic the X+1-Asn part of the minimal phosphopeptide sequence, Ac-pTyr-X+1-Asn-NH2, recognized by the Grb2-SH2 domain. The resulting compounds show the same degree of affinity as their peptide counterparts for the Grb2-SH2 domain. This is the first example reported to date of ligands of the Grb2-SH2 domain with substantially reduced peptidic character.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::40f16375635442b0425d9ad27e5fadf0 https://doi.org/10.1002/chin.199906177 Zobrazit plný text záznamu Plný text