Trial of chlorpropamide in subclinical diabetes
| Autor: | Thorir Helgason, John M. Stowers |
|---|---|
| Rok vydání: | 1965 |
| Předmět: |
Chlorpropamide
Glycosuria Pregnancy medicine.medical_specialty business.industry Endocrinology Diabetes and Metabolism medicine.medical_treatment medicine.disease Bed rest Gastroenterology Surgery Diabetes mellitus Internal medicine Internal Medicine medicine Fasting blood sugar Intravenous Glucose Tolerance Test medicine.symptom business medicine.drug Subclinical infection |
| Zdroj: | Diabetologia. 1:128-130 |
| ISSN: | 1432-0428 0012-186X |
| DOI: | 10.1007/bf00421488 |
| Popis: | A trial is described of the use of small doses of Chlorpropamide for subclinical diabetes, defined as chemical diabetes with a normal fasting blood sugar and without diabetic symptoms. Subjects with subclinical diabetes were investigated for symptomless glycosuria or because of one or more of a number of clinical characteristics known often to be associated with diabetes. Glucose tolerance was measured initially and at intervals by the intravenous technique, the results being expressed numerically as Increment Indices. Precautions were taken to exclude the non-specific influences of loss of excess weight, of bed rest and of pregnancy when assessing the long-term effect of small doses of Chlorpropamide. The Chlorpropamide treatment was temporarily discontinued some three weeks before performing the sequential intravenous glucose tolerance test. Results on 107 subjects showed improvement in glucose tolerance in 78, no change in 2 and deterioration in 27. The most favourable results were obtained in the 30 women under 35 years of age who achieved a normal Increment Index after an average of 121/2 months treatment of Chlorpropamide. A larger scale, double-blind trial is being performed under the auspices of the Medical & Scientific Section of the British Diabetic Association using a placebo-treated control group. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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