New Isoniazid Complexes, Promising Agents Against Mycobacterium tuberculosis
| Autor: | Clarice Queico Fujimura Leite, Fernando Rogério Pavan, María H. Torre, Antonio J. Costa-Filho, Mariana Poggi, Dinorah Gambino, Heloisa B. de Barros, Rafael P. Barroso |
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| Rok vydání: | 2017 |
| Předmět: |
Tuberculosis
biology 010405 organic chemistry Stereochemistry Chemistry Isoniazid General Chemistry 010402 general chemistry biology.organism_classification medicine.disease 01 natural sciences 0104 chemical sciences Mycobacterium tuberculosis Lipophilicity medicine Cytotoxicity IC50 Nuclear chemistry medicine.drug Mycobacterium |
| Zdroj: | Journal of the Mexican Chemical Society. 57 |
| ISSN: | 2594-0317 1870-249X |
| DOI: | 10.29356/jmcs.v57i3.207 |
| Popis: | Tuberculosis (TB) is a public health disease that produces several million deaths annually worldwide. Due to this critical situation and the appearance of drug-resistant microbial strains, innovation in TB drug discovery is a research priority. In this work, the synthesis and characterization by elemental analysis, hermogravimetry, conductimetric measurements and spectroscopies UV-Vis, IR and EPR of [Cu(INH)(H2O)]SO4⋅2H2O (Cu-INH) and [CoCl(INH)2(H2O)] Cl⋅2.5H2O (Co-INH) complexes with isoniazid (INH) are reported. Besides, the lipophilicity, the activity against Mycobacterium tuberculosis (MICCu-INH = 0.78 μg/mL and MICCo-INH = 0.19 μg/mL) and the cytotoxicity (IC50 = 48.8 and 625 μg/mL for the copper and cobalt complexes, respectively) were measured and the selectivity index (62.5 for Cu-INH and 3205 for Co-INH) was calculated. These results indicate that these complexes are good candidates for further studies. |
| Databáze: | OpenAIRE |
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