Cyanocobalamin and 25-Hydroxy Vitamin D Levels in Gout Patients: An Overlooked Issue
| Autor: | Ali Erdem Baki, Hatice Şahin, Ercan Gencer, Muammer Bilici, Metin Isik, Tamer Alışkan, Beyza Kılavuz, Yunus Emre Yandı |
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| Rok vydání: | 2016 |
| Předmět: |
030203 arthritis & rheumatology
Purine Vitamin medicine.medical_specialty business.industry 030204 cardiovascular system & hematology medicine.disease Gastroenterology vitamin D deficiency Gout 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Endocrinology chemistry Internal medicine medicine Vitamin D and neurology Uric acid Cyanocobalamin Vitamin B12 business |
| Zdroj: | Open Journal of Rheumatology and Autoimmune Diseases. :96-101 |
| ISSN: | 2164-005X 2163-9914 |
| Popis: | Gout is one of the most frequent type of inflammatory arthritis in developed countries. The elevation of serum uric acid levels and the deposition of monosodium urate crystals in joints and/or soft tissues are the mechanisms of pathogenesis. Uric acid is a product of the metabolic cleavage of purine nucleotides and organ meats, beef, pork, and lamb, anchovies, sardines, herring, mackerel, scallops, gravy and beer are known to be very rich in purine. On the other hand, some of these foods are also the main sources of vitamin B12 (cyanocobalamin). As a chronic inflammatory arthritis corticosteroids are frequently prescribed for gout patients, meaning a higher risk for osteoporosis which may be blocked by daily calcium and vitamin D replacement. However, there are no recommendations about screening or replacement of Gout patients for vitamin D and B12. Herein, we evaluated our patients retrospectively to document their vitamin levels and also to find the factors associated with vitamin deficiency. Totally, 90 patients, 71 (79.9%) male and 19 (20.1%) female patients with a median diagnostic age of 55 (19 - 80) were included. Thirty six (40%) patients were newly diagnosed (group 1) but 54 (60%) patients had established diseases (group-2) with median disease duration of 36 (11-240) months. Nearly half (47.2%) of the patients in group-1 and 37% of the patients in group-2 had vitamin B 12 deficiency. Similarly, 38.9% in each group had vitamin D deficiency and 52.8% in group-1 and 44.4% in group-2 had vitamin D insufficiency. In conclusion, we strongly recommend routine screening and replacement of vitamin B12 and D for patients with Gout. |
| Databáze: | OpenAIRE |
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