Boron nitride nanotube@NiFe2O4: a highly efficient system for magnetohyperthermia therapy
| Autor: | Dawidson Assis Gomes, Thaylice Cs Cabral, Edesia M.B. de Sousa, Marcelo Coutinho de Miranda, Tiago Hilário Ferreira, José D. Ardisson, L. E. Fernandez-Outon |
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| Rok vydání: | 2019 |
| Předmět: |
Materials science
biology Biomedical Engineering Cancer therapy Medicine (miscellaneous) Nanoparticle Bioengineering Nanotechnology Development biology.organism_classification Boron nitride nanotube HeLa chemistry.chemical_compound chemistry Transmission electron microscopy Boron nitride Mössbauer spectroscopy General Materials Science Single cycle |
| Zdroj: | Nanomedicine. 14:3075-3088 |
| ISSN: | 1748-6963 1743-5889 |
| Popis: | Aim: The field of nanotechnology promotes the development of innovative and more effective cancer therapies. This work is aimed to develop a hybrid system that combines the capacity of boron nitride nanotubes (BNNTs) to be internalized by tumor cells and the ability of nickel ferrite nanoparticles to efficiently release heat by induced AC magnetic heating. Materials & methods: The systems studied were characterized by using x-ray diffractometry, transmission electron microscopy, vibrating sample magnetometry and Mössbauer spectroscopy. Results: The ferrite nanoparticles attached to BNNT were able to achieve the required temperatures for magnetohyperthermia therapies. After cellular internalization, AC induced magnetic heating of BNNT@NiFe2O4 can kill almost 80% of Hela cells lineage in a single cycle. Conclusion: This system can be a highly efficient magnetohyperthermia agent in cancer therapy. |
| Databáze: | OpenAIRE |
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