Reactions with 4-Thiohydantoin. Preparation of 5-Arylidene-4-Thiohydantoin, their Reactions towards Grignard Reagents and the Alkylating Agents

Autor:	A. F. A. Shalaby, H. A. Daboun, S. S. M. Boghdadi
Rok vydání:	1974
Předmět:	chemistry.chemical_classification chemistry.chemical_compound Hydrolysis chemistry Double bond Diazomethane Reagent Hydantoin General Chemistry Methylation Medicinal chemistry Cyclopropane
Zdroj:	Zeitschrift für Naturforschung B. 29:99-103
ISSN:	1865-7117 0932-0776
DOI:	10.1515/znb-1974-1-231
Popis:	4-Thiohydantoin and 1-phenyl-4-thiohydantoin reacted with aromatic aldehydes to give the corresponding 5-arylidene-4-thiohydantoin (1 a-h). la was obtained also from 5-benzylidene hydantoin and phosphorous pentasulphide. Grignard reagents added to the lateral double bond of (1 a-c) to give after hydrolysis the colorless products 3. Treatment of (1a, b) with alkylating agents gave the corresponding alkylmercapto derivatives (4 a-h). Also (4a, e) were obtained by the action of ethereal diazomethane on (1a, b). By further methylation of (4 e) with diazomethane, a cyclopropane derivative could be isolated.
Databáze:	OpenAIRE
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