Facile synthesis of novel polysubstituted thiopene and 1,3,4-thiadiazole derivatives

Autor:	Zaghloul E. Kandeel, Ahmad M. Farag, Kamal M. Dawood
Rok vydání:	1997
Předmět:	Potassium hydroxide chemistry.chemical_compound chemistry Organic Chemistry Drug Discovery 1 3 4 thiadiazole derivatives Thiophene Organic chemistry Biochemistry
Zdroj:	Tetrahedron. 53:161-166
ISSN:	0040-4020
DOI:	10.1016/s0040-4020(96)00959-3
Popis:	3-(Benzothiazol-2-yl)-3-oxopropanenitrile ( 1 ) reacts with phenylisothiocyanate in the presence of potassium hydroxide followed by addition of the hydrazonoyl bromides 2a-c to afford the novel 1,3,4- thiadiazole derivatives 6a-c via the intermediate 4 . Reaction of 4 with 2-bromoacetylbenzothiazole ( 3 ) furnished the new polysubstituted thiophene 13 . Treatment of the latter product with aromatic diazonium salts resulted in the formation of 2-arlazothiophene derivatives 16a-c . A suggested mechanisms of the investigated reactions were presented.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::40b6a794f7edc81b00e156db2a232be5 https://doi.org/10.1016/s0040-4020(96)00959-3 Zobrazit plný text záznamu Full Text from ScienceDirect