Correlation Analysis Between Preoperative Serum Iron Level and Prognosis as Well as Recurrence of HCC After Radical Resection
| Autor: | Weijia Liao, Yicheng Li, Wanying Qin, Wentao Xu, Pu Chen, Zhaoquan Huang, Minjun Liao |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Serum iron level medicine.medical_specialty Receiver operating characteristic medicine.diagnostic_test business.industry Retrospective cohort study medicine.disease Gastroenterology digestive system diseases 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Oncology 030220 oncology & carcinogenesis Hepatocellular carcinoma Internal medicine Correlation analysis medicine Serum iron business Radical resection Survival rate |
| Zdroj: | Cancer Management and Research. 12:31-41 |
| ISSN: | 1179-1322 |
| DOI: | 10.2147/cmar.s227418 |
| Popis: | Background The purpose of this retrospective study was to investigate the relationship between serum iron levels and the prognosis and risk of recurrence in patients with hepatocellular carcinoma (HCC). Methods A total of 253 HCC patients who underwent radical resection were involved in this study. Results According to the receiver operating characteristic (ROC) curve, the optimal cut-off value for preoperative serum iron in the assessment of HCC postoperative prognosis was 94 ug/dL. The overall survival (OS) of patients in the high iron group was significantly better than that in the low iron group (p 5 cm (χ 2 = 11.590, p 5 cm, and microvascular invasion were independent predictors for shorter OS and DFS in HCC patients after operation, while recurrence was for shorter OS. Conclusion Patients with low preoperative serum iron level had worse postoperative survival and higher recurrence rate in HCC. Preoperative serum iron is an independent predictor of HCC patients. For HCC patients with low iron levels, prognosis of patients may be improved if appropriate iron is supplemented. |
| Databáze: | OpenAIRE |
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