Effect of Systemic Administration of Granulocyte-Colony Stimulating Factor on Rate of Fracture Healing of Bone Defect in Goats as Animal Model
| Autor: | Collin S. K. Looi, Nurul H. Khairuddin, Hui Cheng Chen, Rajesh Ramasamy, Seng Fong Lau, Sharifah A. Roohi |
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| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | JULY ISSUE. 18:211-217 |
| ISSN: | 1675-8544 2636-9346 |
| DOI: | 10.47836//mjmhs18.4.28 |
| Popis: | Granulocyte-colony stimulating factor (G-CSF) serves as an important cytokine in haematopoiesis; released at both physiological and pathological conditions by a range of cells. We hypothesized that the systemic administration of G-CSF would produce an accelerated fracture-healing rate in non-union bone defects; thus, potentially leading to useful clinical applications. Ten male adult Katjang goats, weighing about 15-26 kilograms were randomly chosen and a tibial bone defect was induced in each animal. The defect was maintained by internal fixation with a titanium plate and reinforced by an external fiberglass cast. Post-operative radiographs were performed twice weekly and radiographic assessments were performed by evaluating the bridging and union measurements through a validated method. In the treatment group, the time for bridging and union exhibited statistically significant differences when compared with a control group. The outcomes of the present study establishing a notion that administration of G-CSF besides inducing haematopoiesis, promotes healing of fractures and non-union bone defects as well. |
| Databáze: | OpenAIRE |
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