Molecular Mechanisms of Calmodulin Action

Autor: Thomas J. Lukas, H. Michael Harrington, Daniel M. Roberts, D. Martin Watterson
Rok vydání: 1986
Předmět:
Zdroj: Molecular and Cellular Aspects of Calcium in Plant Development ISBN: 9781461292821
Popis: Calcium has many biological functions and several groups of macromolecules have the ability to bind calcium with various selectivities and affinities. A rapidly expanding body of knowledge about the structure, thermodynamic and kinetic properties, and cell biology of calcium binding proteins strongly indicates that the targets or receptors for calcium acting as a signal transducer in eukaryotic cells are a class of calcium binding proteins referred to as calcium modulated proteins. These proteins are characterized by their ability to bind calcium in a reversible manner with dissociation constants in the nanomolar to micromolar range under physiological conditions. Although it is not possible yet to predict with any degree of certainty what type of calcium binding structure or molecular mechanism might be associated with a given biological function of calcium, a trend has begun to emerge from the detailed analyses of calcium modulated proteins1
Databáze: OpenAIRE