Comparative study of simulated nebulized and spray particle deposition in chronic rhinosinusitis patients

Autor:	Olulade O. Fasanmade, Saikat Basu, Brent A. Senior, Adam M. Zanation, William D. Bennett, Erin M. Lopez, Charles S. Ebert, Julia S. Kimbell, Zainab Farzal, Alyssa Burke
Rok vydání:	2019
Předmět:	business.industry medicine.medical_treatment Airflow Spray nozzle 03 medical and health sciences Nebulizer 0302 clinical medicine Paranasal sinuses medicine.anatomical_structure 030228 respiratory system Otorhinolaryngology Nasal spray medicine Immunology and Allergy Deposition (phase transition) Particle 030223 otorhinolaryngology business Biomedical engineering Particle deposition
Zdroj:	International Forum of Allergy & Rhinology. 9:746-758
ISSN:	2042-6976
DOI:	10.1002/alr.22324
Popis:	Background Topical intranasal drugs are widely prescribed for chronic rhinosinusitis (CRS), although delivery can vary with device type and droplet size. The study objective was to compare nebulized and sprayed droplet deposition in the paranasal sinuses and ostiomeatal complex (OMC) across multiple droplet sizes in CRS patients using computational fluid dynamics (CFD). Methods Three-dimensional models of sinonasal cavities were constructed from computed tomography (CT) scans of 3 subjects with CRS refractory to medical therapy using imaging software. Assuming steady-state inspiratory airflow at resting rate, CFD was used to simulate 1-µm to 120-µm sprayed droplet deposition in the left and right sinuses and OMC with spray nozzle positioning as in current nasal spray use instructions. Zero-velocity nebulization simulations were performed for 1-µm to 30-µm droplet sizes, maximal sinus and OMC deposition fractions (MSDF) were obtained, and sizes that achieved at least 50% of MSDF were identified. Nebulized MSDF was compared to sprayed droplet deposition. We also validated CFD framework through in vitro experiments. Results Among nebulized droplet sizes, 11-µm to 14-µm droplets achieved at least 50% of MSDF in all 6 sinonasal cavities. Four of 6 sinonasal cavities had greater sinus and OMC deposition with nebulized droplets than with sprayed droplets at optimal sizes. Conclusion Nebulized droplets may target the sinuses and OMC more effectively than sprayed particles at sizes achieving best deposition. Further studies are needed to confirm our preliminary findings. Several commercial nasal nebulizers have average particle sizes outside the optimal nebulized droplet size range found here, suggesting potential for product enhancement.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::40ab0b6f7fef2fb3bdcd5ec182e79e30 https://doi.org/10.1002/alr.22324 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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